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Ingredient dossier · No. 027

Soy Protein Isolate

Also: SPI · isolated soy protein · soy isoflavones · genistein · daidzein


Probably fine in moderationmeta-analyses don't show meaningful testosterone or sperm effects at normal intakes; whey or pea protein avoids the question entirely.


01 · Hormonal impact

Testosterone & hormonal load

Evidence
ModerateAnimal studies with mechanistic evidence

Soy protein contains phytoestrogens (genistein and daidzein) that weakly bind estrogen receptors. Multiple clinical meta-analyses find no meaningful change in total or free testosterone, LH, FSH, or sperm parameters at typical dietary intakes. Case reports of gynecomastia and very low testosterone exist but involve supraphysiological intakes (over 12 servings daily). For most men consuming 1–2 servings of soy protein daily, the clinical evidence does not support testosterone suppression.


02 · Where it appears

Found in.

01Plant protein powders
02Meal replacement shakes
03Protein bars
04Soy milk
05Tofu and tempeh
06Veggie burgers

03 · The regulators

Two jurisdictions, two different verdicts.

European Union

Soy protein is a common food ingredient. Soy allergen must be declared under EU Food Information Regulation.

United States · FDA

Generally recognized as safe. FDA-allowed health claim: 25g/day soy protein as part of diet low in saturated fat may reduce risk of heart disease.


04 · Sources

The receipts.

  1. [01]
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