Homosalate
Also: homomenthyl salicylate · HMS · 3,3,5-trimethylcyclohexyl salicylate
Avoid — EU restricted concentration in 2021 citing endocrine concerns; FDA categorized as not GRASE pending more safety data.
Testosterone & hormonal load
The EU SCCS reduced the allowable concentration of homosalate in sunscreens from 10% to 1.4% in its 2021 opinion, citing endocrine disruption potential. Homosalate shows estrogenic activity in cell studies and anti-androgenic activity in androgen receptor reporter assays. FDA's 2021 sunscreen monograph update classified it as 'not GRASE' pending additional toxicology data.
Found in.
Two jurisdictions, two different verdicts.
SCCS/1622/20 (2021) recommended reduction from 10% to 1.4% maximum; endocrine disruption flagged as the primary concern.
Classified as 'not GRASE' in the 2021 proposed sunscreen monograph update, requiring additional safety data.
The receipts.
- [01]SCCS/1622/20 — Opinion on Homosalate (EU, 2021)ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_250.pdf
- [02]FDA — OTC sunscreen proposed order Q&Awww.fda.gov/drugs/understanding-over-counter-medicines/questions-and-answers-fda-posts-deemed-final-order-and-proposed-order-over-counter-sunscreen
- [03]Krause et al. 2012 — Sunscreens and endocrine disrupting properties of UV-filters (PubMed)pubmed.ncbi.nlm.nih.gov/22612478/
Find Homosalate before it finds you.
Point the camera at any barcode. Mangood reads the ingredient list and tells you, in one tap, whether Homosalate is hiding in the bottle in your hand.