Octocrylene
Also: 2-ethylhexyl 2-cyano-3,3-diphenylacrylate · 2-ethylhexyl (2E)-2-cyano-3,3-diphenylacrylate
Avoid — degrades into benzophenone over time, raising both endocrine and carcinogenicity concerns.
Testosterone & hormonal load
Octocrylene itself has modest estrogenic activity in vitro, but the bigger concern is its degradation product: benzophenone, which IARC classifies as possibly carcinogenic to humans (Group 2A) and which is a known endocrine disruptor. Octocrylene accumulates in products over shelf life, meaning that older sunscreens may contain significant benzophenone levels. Studies have found benzophenone contamination in sunscreen and lip balm products on store shelves.
Found in.
Two jurisdictions, two different verdicts.
Permitted at up to 9% in sunscreens. Under SCCS review; EU consumer groups have flagged benzophenone degradation.
Classified as 'not GRASE' in the 2021 proposed sunscreen monograph update pending additional safety data.
The receipts.
- [01]Downs et al. 2021 — Benzophenone accumulates from octocrylene degradation (PubMed)pubmed.ncbi.nlm.nih.gov/33682414/
- [02]FDA — OTC sunscreen proposed order Q&Awww.fda.gov/drugs/understanding-over-counter-medicines/questions-and-answers-fda-posts-deemed-final-order-and-proposed-order-over-counter-sunscreen
Find Octocrylene before it finds you.
Point the camera at any barcode. Mangood reads the ingredient list and tells you, in one tap, whether Octocrylene is hiding in the bottle in your hand.