Octinoxate (Ethylhexyl Methoxycinnamate)
Also: ethylhexyl methoxycinnamate · OMC · EHMC · octyl methoxycinnamate
Avoid — estrogenic in animal models and absorbed systemically; safer mineral alternatives exist.
Testosterone & hormonal load
Octinoxate (OMC) binds estrogen receptors and shows estrogenic activity in uterotrophic assays. Animal studies demonstrate thyroid hormone disruption at repeated exposure doses. It is measurably absorbed through skin into the bloodstream. While human evidence for testosterone effects is limited, its estrogenic and thyroid-disrupting properties represent a concern for men's hormonal health when applied daily.
Found in.
Two jurisdictions, two different verdicts.
Permitted at up to 7.5% in sunscreens. Under review for endocrine disruption classification by SCCS.
One of the sunscreen filters FDA proposed reclassifying to 'not GRASE' in its 2019/2021 proposed rules pending additional safety data.
The receipts.
- [01]Klammer et al. 2007 — OMC effects on hypothalamo-pituitary-thyroid function (PubMed)pubmed.ncbi.nlm.nih.gov/17651886/
- [02]Schlumpf et al. 2001 — In vitro and in vivo estrogenicity of UV screens (PubMed)pubmed.ncbi.nlm.nih.gov/11333184/
- [03]FDA — OTC sunscreen proposed order Q&Awww.fda.gov/drugs/understanding-over-counter-medicines/questions-and-answers-fda-posts-deemed-final-order-and-proposed-order-over-counter-sunscreen
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