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Ingredient dossier · No. 035

Zinc

Also: zinc citrate · zinc gluconate · zinc picolinate · zinc oxide · ZMA


Take if deficientwell-established role in testosterone and sperm production; megadosing won't push T above normal in already-replete men.


01 · Hormonal impact

Testosterone & hormonal load

Evidence
StrongMultiple human or large-scale animal studies

Zinc is an essential cofactor for testosterone biosynthesis in Leydig cells and for aromatase regulation. Controlled human studies demonstrate that dietary zinc restriction leads to a 75% reduction in serum testosterone within 20 weeks in young men, and zinc supplementation in deficient men normalizes testosterone levels. However, supraphysiological zinc intake in replete men does not further elevate testosterone. Zinc also plays a key role in sperm morphology and motility.


02 · Where it appears

Found in.

01Men's multivitamins
02Testosterone booster formulas
03ZMA supplements
04Immune support supplements
05Sunscreen (zinc oxide)

03 · The regulators

Two jurisdictions, two different verdicts.

European Union

Permitted in food supplements with established upper intake levels (25 mg/day for adults, EFSA). Zinc oxide permitted in cosmetics including sunscreen.

United States · FDA

Generally Recognized as Safe (GRAS) as a dietary supplement. Zinc oxide is Category I (safe and effective) for sunscreen use. Tolerable upper intake level: 40 mg/day (NIH).


04 · Sources

The receipts.

  1. [01]
  2. [02]
  3. [03]
    NIH Office of Dietary Supplements — Zinc Fact Sheet
    ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

05 · Related dossiers
01MagnesiumB · 7602BoronB · 7003Vitamin D3 (Cholecalciferol)A · 88
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